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Acromegaly was the first pituitary disease to be recognised as a clinical entity, although initially it was not clear whether the eosinophilic adenomas causing pituitary enlargement were causative or just a manifestation of the syndrome itself. Following the documented clinical improvement of patients with acromegaly after partial hypophysectomy, it was proven that the pituitary adenomas were aetiological. The treatment of acromegaly has changed during the last decades; the introduction of the somatostatin SMS analogue octreotide has had major implications. Octreotide was the first SMS analogue to become available for clinical use.
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A Risk-Benefit Assessment of Octreotide in the Treatment of Acromegaly

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A Risk-Benefit Assessment of Octreotide in the Treatment of Acromegaly | SpringerLink

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A Risk-Benefit Assessment of Octreotide in the Treatment of Acromegaly

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